Understanding Solid-Based Platelet-Rich Fibrin Matrices in Oral and Maxillofacial Surgery: An Integrative Review of the Critical Protocol Factors and Their Influence on the Final Product

Medicina 2023; 59,1903. DOI: 10.3390/medicina59111903.

Autores: Ángel-Orión Salgado-Peralvo, Naresh Kewalramani, Alba Pérez-Jardón, Jesús Pato-Mourelo, Adriana Castro-Calderón, Lorenzo Arriba-Fuente and Mario Pérez-Sayáns.

Abstract: 

Platelet-rich fibrin (PRF) is a second-generation platelet concentrate whose use in clinical practice has been widely disseminated. This has led to the development of several commercial protocols, creating great confusion as to the terminology and implications of each of them. This integrative review aims to identify the critical factors of each of the phases of the solid-based PRF matrix protocol and their possible influence on their macro- and microscopic characteristics. An electronic search of the MEDLINE database (via PubMed), Web of Science, Scopus, LILACS, and OpenGrey was carried out. The search was temporarily restricted from 2001 to 2022. After searching, 43 studies were included that met the established criteria. There were numerous factors to consider in the PRF protocol, such as the material of the blood collection tubes, the duration of phlebotomy, the parameters related to blood centrifugation, the time from centrifugation to dehydration of the fibrin clots and their dehydration into membranes, as well as the time to clinical use. These factors influenced the macro- and microscopic characteristics of the PRF and its physical properties, so knowledge of these factors allows for the production of optimised PRF by combining the protocols and materials.

DESCARGAR ARTÍCULO

Comparison of the effectiveness of two manual toothbrushes: Conventional design versus double-sided toothbrush design. A pilot study

International Journal of Dental Hygiene 2023; Online ahead of Print. DOI: 10.1016/j.prosdent.2023.07.021

Autores:  Fabián Pérez-González, Luis-Miguel Sánchez-Alcaide, Luis Sánchez-Labrador, María-Victoria Mateos-Moreno, María-Rosario Garcillán-Izquierdo, and Angel-Orión Salgado-Peralvo.

Abstract: 

Objectives: Dental hygiene is the most effective method in the prevention of oral diseases. However, most patients do not use the recommended teeth brushing tech- niques and/or time brushing is insufficient. With this objective, modifications in con- ventional toothbrushes have been developed to deal with these findings. The aim of this study was to compare plaque removal effectiveness of a manual toothbrush with a modified head (MTMH) with a wrap-around design versus a conventional manual toothbrush.

Methods: This pilot prospective clinical study was designed according to STROBE guidelines. The patients suspended oral hygiene habits for 24 h (baseline). Subsequently, the teeth were brushed for 60 s. Both toothbrushes followed the same study procedure, separated by 1 month. Plaque-removing effectiveness was meas- ured before and after tooth brushing using the modified O'Leary Plaque Index (PI).

Results: Seven patients were included in this pilot study. The mean age was 37.66 ± 10.68 years. PI mean differences between baseline and after brushing were 51.99% ±16.43 for MTMH and 27.93 ± 6.85, for conventional toothbrush (p = 0.0013). After brushing, mean PI values were 18.36% ± 6.95%, and 37.61% ± 10.57% respec- tively (p < 0.001).

Conclusions: Within the limitations of the present study, it can be concluded that the effectiveness of plaque removal by using MTMH is significantly higher than the con- ventional manual toothbrush.

DESCARGAR ARTÍCULO

Evaluating the clinical behavior of veneered zirconia in comparison with monolithic zirconia complete arch implant-supported prostheses: A systematic review and meta-analysis

The Journal of Prosthetic Dentistry 2023; Online ahead of Print. DOI: 10.1111/idh.12769

Autores: Sara Martakoush-Saleh, Angel-Orión Salgado-Peralvo, Juan-Francisco Peña-Cardelles, Naresh Kewalramani, and German O. Galluci.

Abstract: 

Statement of problem: Since the use of zirconia in dentistry is relatively new, the number of published studies on the subject is scarce, even though material selection is an important factor in clinical performance. Therefore, a systematic assessment of the impact of the prosthetic material, framework design, veneering material, and manufacturing process is required.

Purpose: The purpose of this systematic review and meta-analysis was to investigate the survival and success rates of feldspathic porcelain veneered zirconia (VZir) in comparison with monolithic zirconia (MZir) complete arch implant-supported prostheses (CAISPs). A secondary objective was to assess the influence of the type of loading, the presence or absence of a cantilever, the type of zirconia used, the location, and the opposing arch on complications rates and patient satisfaction.

Material and methods: An electronic search of the MEDLINE database (via PubMed), Scopus, Science Direct, Cochrane Library, and OpenGrey was carried out. The criteria described in the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement were used. The search was restricted from January 2000 to January 2022.

Results: The systematic search resulted in 20 articles that met the established criteria. In total, 751 patients (VZir=302; MZir=449) with 3038 CAISPs (VZir=368; MZir=2670) were analyzed. Higher prosthetic survival and success rates were found in MZir compared with VZir CAISPs (100% and 95.45%, respectively). The meta-analysis found significantly fewer complications related to MZir (9.4% [4.8%-14.1%]) compared with VZir (33.7% [17.5%-49.9%]).

Conclusions: Based on the findings of this systematic review, MZir CAISPs had higher survival and success rates than VZir CAISPs, with significantly fewer prosthetic complications. The influence of factors such as the type of functional loading, the presence of a cantilever, the material used in the prosthodontic workflow, the location of the CAISP, and the type of antagonist arch in the performance of Zir CAISPs remains unclear.

DESCARGAR ARTÍCULO

Preventive Antibiotic Therapy in sinus elevation procedures: A systematic review

International Journal of Oral and Maxillofacial Surgery 2023; 38(1): 19-28. DOI: 10.11607/jomi.9930 

Autores: Angel-Orión Salgado-Peralvo, Alvaro Garcia-Sanchez, Naresh Kewalramani, Mario Romandini and Eugenio Velasco-Ortega.

Abstract: 

Purpose: To study whether the use of preventive antibiotic therapy reduces the sinus graft infection and/or dental implant failure rates in maxillary sinus elevation surgeries (primary outcome), and to identify the associated best protocol (secondary outcome).

Materials and Methods: The MEDLINE (via PubMed), Web of Science, Scopus, LILACS, and OpenGrey databases were searched between December 2006 and December 2021. Prospective and retrospective comparative clinical studies with at least 50 patients and published in English were included. Animal studies, systematic reviews and meta-analyses, narrative literature reviews, books, case reports, letters to the editor, and commentaries were excluded. Assessment of the identified studies, data extraction, and risk of bias were performed independently by two reviewers. Authors were contacted if required. Collected data were reported by descriptive methods. 

Results: A total of 12 studies fulfilled the inclusion criteria. The only retrospective study comparing the use of antibiotics vs no use of them showed no statistically significant differences for implant failure; however, no data were reported for sinus infection rates. The only randomized clinical trial comparing different courses of antibiotics (only the day of surgery vs 7 additional postoperative days) reported no statistically significant differences between groups in terms of sinus infection rate. 

Conclusion: Not enough evidence is available to support either the use or nonuse of preventive antibiotic therapy for sinus elevation surgeries or to support the superiority of any protocol over others

DESCARGAR ARTÍCULO

Static Computer-Aided Implant surgery: An ally against bacterial antimicrobial resistance?

International Dental Journal 2023; 73: 326-7. DOI:  10.1016/j.identj.2022.12.004

Autores: Juan-Francisco Peña-Cardelles,  Ignacio Pedrinaci, Elli Kotina, Alejandro Lanis, and Angel-Orión Salgado-Peralvo.

DESCARGAR ARTÍCULO

State of the Oral Implantology practice in Spain during the COVID-19 pandemic: A cross-sectional survey

International Journal of Environmental Research and Public Health 2023; 20:1743. DOI:  10.3390/ijerph20031743 

Autores: Angel-Orión Salgado-Peralvo, Daniel Fernández-Cerero, Alvaro García Sanchez, Naresh Kewalramani, Eugenio Velasco-Ortega, Alvaro Jiménez-Guerra, et al..

Abstract: 

At the beginning of the COVID-19 pandemic, strict measures of confinement and social distancing were taken. Dentists were considered essential personnel and their activity was restricted to emergency treatment. The present observational study aims to determine the situation of oral implantology practice in Spain during the initial period of the COVID-19 pandemic. This is a cross- sectional observational study based on the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines. An electronic survey consisting of three blocks of questions was sent to all members of the Spanish Society of Implants. The data were analyzed using descriptive analysis. A total of 237 participants (14.3%) responded to the questionnaire. The majority of partici- pants (60.8%) only attended emergencies during the first 9 months of the pandemic. Despite this, 77.2% reported having performed dental implant surgeries and 75.5% indicated that they performed non-essential treatments. The activity was fully recovered by 64.1% of the surveyed dentists. The majority of dentists (90.7%) considered that sufficient/adequate preventive measures were carried out at their workplace, which possibly contributed to the fact that 49.3% were not afraid of becoming infected. This concern was significantly and directly proportionally associated with the age of the surveyed dentists. The oral implant practice was affected to a greater extent during the first 9 months of the pandemic, especially in urban areas, with a greater impact on the workload of professionals with less specialised training in oral implantology.

DESCARGAR ARTÍCULO

Antibiotic resistance: The silent pandemia (in the COVID-19 era)

International Dental Journal 2023; 73: 328-9. DOI:  10.1016/j.identj.2023.01.003

Autores: Angel-Orión Salgado-Peralvo, Naresh Kewalramani, and María-Victoria Mateos-Moreno.

DESCARGAR ARTÍCULO

Restoring the functionality of implant-supported prostheses with a reloading technique: A clinical report

The Journal of Prosthetic Dentistry 2023; [Online Ahead of Print]. DOI: 10.1016/j.prosdent.2022.11.021

Autores: Angel-Orión Salgado-Peralvo,  Naresh Kewalramani, Antonio Liñares and Jesús Peláez-Rico.

Abstract: 

The prevalence of infraocclusion and/or loss of interproximal contact areas with implant-supported restorations is high, and replacement of these prostheses has been advocated for the treatment of mild or moderate infraocclusion; however, replacement is complicated if the manufacturer of the implant is unknown. A technique is presented for correcting the infraocclusion of posterior prostheses that are directly connected to the implant. Advantages include possibly preventing marginal bone loss secondary to the removal and reconnection of the prosthetic attachments and reducing the number of appointments.

DESCARGAR ARTÍCULO

Situación de la práctica implantología en España durante los 18 primeros meses de la pandemia de COVID-19

Sociedad Española de Implantes, 2023

Autores: Angel-Orión Salgado-Peralvo, Alvaro Garcia-Sanchez, Naresh Kewalramani,  Eugenio Velasco-Ortega, José López López, Álvaro Jiménez Guerra,  Jesús Moreno Muñoz, Enrique Núñez Márquez and Loreto Monsalve Guil.

Abstract: 

Además, la SEI elaboró un protocolo original de encuesta para conocer el grado de afectación de nuestra actividad profesional que fue realizado por un grupo de expertos, que se realizó durante los últimos meses de 2021 y comienzo de 2022, y que presentamos en este documento. Los resultados son muy interesantes y pueden ayudarnos como sociedad científica a vislumbrar la importancia de nuestra profesión en determinadas circunstancias muy difíciles como las acontecidas como consecuencia de la pandemia por COVID-19.

DESCARGAR ARTÍCULO

Treatment of sinus membrane perforations during sinus lift surgeries using Leukocyte and Platelet-Rich Fibrin: A report of three cases

Journal of Clinical and Translational Research 2022; 8(5): 360-8. DOI: 10.18053/jctres.08.202205.006 

Autores: Angel-Orión Salgado-Peralvo, Alvaro Garcia-Sanchez, Naresh Kewalramani, and Eugenio Velasco-Ortega.

Abstract: 

Background and Aim: Schneiderian membrane (SM) perforation is the most frequent intraoperative complication during sinus lifts, which can lead to implant failure or delayed implant treatment. This article aims to show the results of using leukocyte and platelet-rich fibrin (L-PRF) in the treatment of perforations occurring during sinus lifts with a lateral window approach.

Results: Three patients (n = 5 implants) with a mean ± SD age of 57.67 ± 12.12 years were included, in whom perforations of the SM of 3–5 mm and >5 mm occurred. The mean ± SD preoperative bone height was 4.42 ± 2.96 and, at 6 months it was 9.58 ± 2.41 (P < 0.05). All implants had a 100% survival rate at 6–24 months. At the split-mouth, the mean ± SD baseline height was 5.05 ± 2.99 mm in repaired SM versus 2.92 ± 1.01 in those without any complications (P > 0.05). At 6 months, mean ± SD gains were 10.09 ± 2.44 mm versus 7.73 ± 0.90 mm, respectively, (P > 0.05).

Conclusion: L-PRF simplifies SM repair, reducing the need for high surgical experience and/or skills. Although there are no significant differences between repaired and intact SM, at the radiological level, greater bone compactness and maturation were observed in the latter, which may be associated with the presence of air bubbles caused by anaerobic bacterial activity in repaired SM.

Relevance for Patients: The use of L-PRF greatly simplifies the resolution of SM perforations during sinus lift surgeries, reducing treatment times, and providing predictable results. Being of autologous origin, it accelerates and enhances healing, eliminating the possibility of autoimmune rejection reactions.

DESCARGAR ARTÍCULO

Prevalence of aphthous stomatitis in patients with inflammatory bowel disease after the treatment with monoclonal antibodies: a systematic review and meta-analysis

Medicina Oral, Patología Oral, Cirugía Bucal 2022; 27(6):e588-99. DOI: 10.4317/medoral.25528

Autores: Angel-Orión Salgado-Peralvo, María Montero-Alonso, Naresh Kewalramani, Mario Pérez-Sayáns-García, María-Victoria Mateos-Moreno, and María-Rosario Garcillán-Izquierdo.

Abstract: 

Background: Currently, the most frequently employed therapies in the treatment of inflammatory bowel diseases (IBD), i.e., Crohn's Disease (CD), Ulcerative Colitis (UC) or unclassified IBD (IBD-U) are monoclonal anti-TNFs and anti-integrin therapies, such as vedolizumab (VDZ). Forty-seven per cent of these patients present extra- intestinal manifestations, the second most prevalent being aphthous stomatitis (AS). The present study aims to investigate which of the two therapies is associated with a lower prevalence of AS after treatment.

Material and Methods: An electronic search of the MEDLINE (via PubMed), Web of Science, SCOPUS, LILACS and OpenGrey databases was carried out. The criteria used were those described by the PRISMA Statement. The search was not temporarily restricted and was updated to January 2022. The quality assessment was analyzed us- ing the JBI Prevalence Critical Appraisal Tool.

Results: After searching, 7 studies were included that met the established criteria. Of these, 6 analysed the preva- lence of AS in CD patients and 4 in UC. A total of 1,744 patients were analysed (CD=1,477 patients; 84.69%; UC=267; 15.31%). The greatest reduction in AS prevalence was observed after anti-TNF therapy. The effect of these therapies on the prevalence of AS in patients with IBD-U could not be determined.

Conclusions: Both biologic therapies achieve a reduction in the prevalence of AS in IBD patients (CD and UC). However, the best results were obtained in patients treated with anti-TNFs, possibly because VDZ is often used in patients who do not respond adequately to previous treatment with anti-TNFs and because of its intestinal specificity.

DESCARGAR ARTÍCULO

Selective Serotonin Reuptake Inhibitors as a risk factor for dental implant failure: A retrospective clinical study

British Journal of Oral & Maxillofacial Surgery  2022; 60(10):1347-52. DOI: 10.1016/j.bjoms.2022.09.009

Autores: Karen Rodríguez-Pena, Angel-Orión Salgado-Peralvo, Naresh Kewalramani, Juan-Antonio Suárez-Quintanilla, and José-María Suárez-Quintanilla.

Abstract: 

Introduction: The trend in recent decades in Europe and the United States points to an exponential increase in the consumption of antidepressant drugs and, in particular, selective serotonin reuptake inhibitors (SSRIs). This retrospective study aims to investigate whether there is an association between SSRI intake and dental implant (DI) failure and, secondarily, the influence of other systemic and local factors.

Material and Methods: This cohort retrospective study is in concordance with the STROBE guidelines for observational studies. One-hundred seventy patients received 573 DIs between 2014 and 2020.
Results: The reported DI failure rate was 6.11%. Of these, 18.31% failed in patients treated with SSRIs while 4.38% failed in healthy patients (p<0.001). Specifically, the use of these drugs was associated with a 4.53 times higher rate of DI failure, and, in the multivariate analysis, 3.70 times higher adjusted risk was found. A lower survival rate at 90 months follow-up was also observed in these patients compared to those not taking these drugs (84.30% vs. 96%; p=0.00014).

Conclusions: With the limitations of the present study, it can be affirmed that there is a relationship between the intake of SSRIs and DI failure, as well as a lower survival rate in these patients.
 

DESCARGAR ARTÍCULO

Do platelet concentrates accelerate orthodontic tooth movement? A systematic review

Journal of Periodontal & Implant Science 2023; 53(1): 2-19. DOI: 10.5051/jpis.2201600080

Autores: Sergio Herrero-Llorente, Angel-Orión Salgado-Peralvo, and Jan G.J.H. Schols.

Abstract: 

Purpose: Surgical techniques in orthodontics have received widespread attention in recent years. Meanwhile, biomaterials with high molecular content have been introduced, such as platelet concentrates (PCs), which may accelerate orthodontic tooth movement (OTM) and reduce periodontal damage. The present systematic review aimed to answer the following PICO question: “In patients in whom orthodontic surgical techniques are performed (P), what is the effectiveness of using PCs over the surgical site (I) when compared to not placing PCs (C) to achieve faster tooth movement (O)?”

Methods: A search was performed in 6 databases. The criteria employed were those described in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses declaration. The present review included studies with a control group that provided information about the influence of PCs on the rate of OTM.

Results: The electronic search identified 10 studies that met the established criteria.

Conclusions: The included studies were very diverse, making it difficult to draw convincing conclusions. However, a tendency was observed for OTM to be accelerated when PCs were used as an adjuvant for canine distalization after premolar extraction when distalization was started in the same session. Likewise, studies seem to indicate an association between PC injection and the amount of canine retraction. However, it is not possible to affirm that the use of PCs in corticotomy shortens the overall treatment time, as this question has not been studied adequately.

DESCARGAR ARTÍCULO

The use of Platelet-Rich Fibrin in vestibuloplasty: A 36-month follow-up technique report

Clinical Advances in Periodontics  2022; 13. 33-7. DOI: 10.1002/cap.10201

Autores: Angel-Orión Salgado-Peralvo, Andrea Uribarri, Naresh Kewalramani, Juan-Francisco Peña-Cardelles, and Antonio Liñares.

Abstract: 

Introduction: Vestibuloplasty is a mucogingival procedure that aims to increase the vestibule and the amount of keratinized tissue (KT) around teeth and dental implants. Currently, the gold standard in this procedure is still represented by free gingival grafts (FGGs); however, they require a second surgical site, which means more morbidity for the patient and a higher risk of surgical complications, as well as surgical time and chromatic alteration of the recipient area.

Case Presentation: This is a description of the vestibuloplasty technique with Platelet-Rich Fibrin (PRF) in a 35- year-old female patient with a thin gingival phenotype and no medical history of interest. The reason for consultation was tooth sensitivity during brushing and the presence of recessions in the fifth sextant.

Conclusions: The use of PRF as a graft biomaterial in vestibuloplasty is a valid and effective option as an alternative to secondary epithelialization of the surgical site, as well as to FGGs, with acceptable results in terms of KT gain and root coverage, and with minimal postoperative discomfort.

DESCARGAR ARTÍCULO

Consensus Report on Preventive Antibiotic Therapy in Dental Implant Procedures: Summary of Recommendations from the Spanish Society of Implants

Antibiotics  2022; 11; 655. DOI: 10.3390/antibiotics/11050655

Autores: Angel-Orión Salgado-Peralvo, Alvaro Garcia-Sanchez, Naresh Kewalramani, Antonio Barone, José-María Martínez-González, Eugenio Velasco-Ortega, et al.

Abstract: 

Current patterns of preventive antibiotic prescribing are encouraging the spread of an- timicrobial resistance. Recently, the Spanish Society of Implants (SEI) developed the first clinical practice guidelines published to date, providing clear guidelines on how to prescribe responsible and informed preventive antibiotic therapy (PAT) based on the available scientific evidence on dental implant treatments (DIs). The present document aims to summarise and disseminate the recom- mendations established by this expert panel. These were based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies were analysed using the Scottish Intercollegiate Guidelines Network (SIGN) checklist templates and ranked according to their level of evidence. They were then assigned a level of recommendation using the Grading of Recommendations, Assessment, Development and Evaluation system (GRADE). Guidelines were established on the type of PAT, antibiotic and dosage of administration in the placement of DIs without anatomical constraints, in bone augmentation with the placement of DIs in one or two stages, placement of immediate DIs, sinus elevations, implant prosthetic phase, as well as recommendations in patients allergic to penicillin. Therefore, the PAT must be adapted to the type of implant procedure to be performed.

DESCARGAR ARTÍCULO

Does the prosthetic phase of dental implants justify the prescription of preventive antibiotics in healthy patients? A systematic review

Journal of Oral Implantology  2022; 3. DOI:10.1563/aaid-joi-D-21-00213.

Autores: Angel-Orión Salgado-Peralvo, Andrea Uribarri, Juan-Francisco Peña-Cardelles, Naresh Kewalramani, Jorge-Luis Garnier-Rodríguez and Eugenio Velasco-Ortega.

Abstract: 

Introduction: Recently published surveys data show that the routine prescription of preventive antibiotics (PA) in the prosthetic phase of dental implants is more common than might be expected. The present study aimed to answer the PICO question " In healthy patients starting the implant prosthetic phase, does the prescription of PA compared to not prescribing PA decrease the incidence of infectious complications? " by a systematic literature review.

Material and methods: A search was performed in 5 databases. The criteria employed were those described in the PRISMA® Declaration. Studies included were those that provided information on the need to prescribe PA in the prosthetic phase of implants, i.e., in second-stage surgeries, impression-taking and prosthesis placement.

Results: The electronic search identified three studies that met the established criteria.

Conclusions: The prescription of PA in the prosthetic phase of implants does not show a justified benefit/risk ratio. PA may be indicated in the second stages or in peri-implant plastic surgery procedures lasting more than two hours and/or where soft tissue grafts are used extensively. In these cases, given the current lack of evidence, it is recommended to prescribe 2 g of amoxicillin 1 h before surgery and, in allergic patients, to prescribe 500 mg of azithromycin 1 h preoperatively.

DESCARGAR ARTÍCULO

Treatment of Oroantral Communications with Platelet-Rich Fibrin: A systematic review.

Journal of Stomatology, Oral and Maxillofacial Surgery  2023; 49(1); 93-101. DOI: 10/1016/j.jormas.2022.03.014 

Autores: Angel-Orión Salgado-Peralvo, María-Victoria Mateos-Moreno, Andrea Uribarri, Naresh Kewalramani, Juan-Francisco Peña-Cardelles and Eugenio Velasco-Ortega.

Abstract: 

Background: Oroantral communication (OAC) is the opening between the maxillary sinus and the oral cavity, which constitutes a gate for the mucosal infection in the maxillary sinus. On the other hand, an OAF develops when the OAC does not close spontaneously, remains manifest and is epithelialized. Several methods have been proposed to solve these situations, however, they are associated with increased postoperative morbid- ity and/or higher associated costs and require some experience of the surgeon to perform them. To overcome these disadvantages, the use of Platelet-Rich Fibrin (PRF) is proposed. The present study aims to perform a systematic review of the literature, collecting cases in which PRF was used in the treatment of OACs/OAFs. 

Materials and methods: An electronic search of the MEDLINE database (via PubMed) and Web of Science was performed using the following MeSH terms (Medical Subjects Headings): (oroantral communication OR oroantral fistula OR buccosinusal communication) AND (platelet-rich fibrin OR prf OR fibrin mesh). The crite- ria used were those described by the PRISMA! Statement. The search was not time-restricted and was updated to April 2021.

Results: After searching, 11 articles were included that met the established criteria. In these, PRF was used alone or in combination with bi- or trilaminar techniques achieving complete resolution in 100% of cases (n = 116).

Conclusions: With the limitations of this study, it can be established that PRF can be used alone for the treat- ment of OACs/OAFs up to 5 mm and, in larger defects, it is advisable to combine it with bi- or trilaminar tech- niques. PRF is an effective therapeutic option, with minimal associated postoperative morbidity compared to other techniques and allows the position of the mucogingival junction to be preserved. Its combination with bone grafting improves the starting point before the replacement of the missing tooth with a dental implant.

DESCARGAR ARTÍCULO

Efficacy of pre-procedural mouthwashes against SARS-CoV-2: A systematic Review of Randomized Controlled Trials.

Journal of Clinical Medicine  2022; 11; 1692. DOI: 10.3390/jcm11061692

Autores: Alvaro García-Sánchez, Juan-Francisco Peña-Cardelles, Steve Ruiz, Flor Robles, Esther Ordonez-Fernandez, Angel-Orión Salgado-Peralvo, James Balloch, and Jacob C. Simon.

Abstract: The oral mucosa is one of the first sites to be affected by the SARS-CoV-2. For this reason, healthcare providers performing aerosol-generating procedures (AGPs) in the oral cavity are at high risk of infection with COVID-19. The aim of this systematic review is to verify whether there is evidence in the literature describing a decrease in the salivary viral load of SARS-CoV-2 after using different mouthwashes. An electronic search of the MEDLINE database (via PubMed), Web of Science, SCOPUS, and the Cochrane library database was carried out. The criteria used were those described by the PRISMA® Statement. Randomized controlled trial studies that have used mouthwashes as a form of intervention to reduce the viral load in saliva were included. The risk of bias was analyzed using the Joanna Briggs Institute Critical Appraisal Tool. Ultimately, eight articles were included that met the established criteria. Based on the evidence currently available in the literature, PVP-I, CHX and CPC present significant virucidal activity against SARS-CoV-2 in saliva and could be used as pre-procedural mouthwashes to reduce the risk of cross-infection.

DESCARGAR ARTÍCULO

Autotransplantation of teeth with incomplete root formation: Systematic Review and Meta-analysis.

Clinical Oral Investigations 2022. DOI: 10.1007/s00784-022-04435-8.

Autores: Javier Sicilia-Pasos, Naresh Kewalramani, Juan-Francisco Peña-Cardelles, Angel-Orión Salgado-Peralvo, Cristina Madrigal-Martínez-Pereda y Angel López-Carpintero..

Abstract: 

Objectives: To determine the survival of intentional autotransplantation of developing teeth.

Material and methods: An electronic search was carried out in the MEDLINE database, Web of Science, and Cochrane Library. The criteria used are the ones described in the PRISMA Declaration. The following MeSH terms were used: ("tooth" [MeSH Terms] OR "tooth" [All Fields]) AND ("transplantation, autologous" [MeSH Terms] OR ("transplantation" [All Fields] AND "autologous" [All Fields]) OR "autologous transplantation" [All Fields] OR "autotransplantation" [All Fields]) AND ("humans" [MeSH Terms]. Randomised clinical trials and prospective and retrospective clinical studies were included. 

Results: The meta-analytic study of overall survival included a total of 14 studies, yielding an overall survival rate of 97.9%. In studies with 1-year follow-ups, survival was 98%. The resulting 2-year follow-up rate was 97%, while the 5- and 10-year survival rates were 95.9% and 96.9%, respectively.

Conclusions The autotransplantation technique performed in a single-phase and on teeth that have not completed their development is a predictable technique, with a described survival rate at a 2-year follow-up of more than 97%.

Clinical Relevance: The technique of dental autotransplantation is considered an important resource for the resolution and rehabilitation of tooth loss in patients, especially in those who are still in a growth period. Moreover, this technique has a low complication rate and a 10-year survival rate of 96.9%. It should therefore be considered a safe and reliable procedure

DESCARGAR ARTÍCULO

Virucidal activity of different mouthwashes against the salivary load of SARS-CoV-2: A narrative review.

Healthcare 2022; 10; 469. DOI: 10.3390/healthcare10030469.

Autores: Alvaro García-Sánchez, Juan-Francisco Peña-Cardelles, Angel-Orión Salgado-Peralvo, Flor Robles, Esther Ordonez-Fernandez, Steve Ruiz y Dániel Végh.

Abstract: The saliva of COVID-19-confirmed patients presents a high viral load of the virus. Aerosols generated during medical and dental procedures can transport the virus and are a possible causative agent of cross-infection. Since the onset of the pandemic, numerous investigations have been at- tempting to mitigate the risk of transmission by reducing the viral load in saliva using preprocedural mouthwashes. This study aims to review the most up-to-date in vitro and in vivo studies investigat- ing the efficacy of different mouthwashes on reducing the salivary viral load of SARS-CoV-2, giving particular attention to the most recent randomized control trials published.

DESCARGAR ARTÍCULO

Povidone-Iodine as a pre-procedural mouthwash to reduce the salivary viral Load of SARS-CoV-2: A systematic review of Randomized Clinical Trials.

International Journal of Environmental Research and Public Health 2022 19;2877. DOI: 10.3390/ijerph19052877

Autores: Alvaro García-Sánchez, Juan-Francisco Peña-Cardelles, Esther Ordóñez-Fernandez, María Montero-Alonso, Naresh Kewalramani, Angel-Orión Salgado-Peralvo, et al.

Abstract: The use of pre-procedural rinses has been investigated to reduce the number of viral par- ticles and bacteria in aerosols, potentially decreasing the risk of cross-infection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during medical and dental procedures. This re- view aims to confirm whether there is evidence in the literature describing a reduction in salivary load of SARS-CoV-2 when povidone-iodine (PVP-I) is used as a pre-intervention mouthwash. An search of the MEDLINE, Embase, SCOPUS, and the Cochrane library databases was conducted. The criteria used followed the PRISMA® Statement guidelines. Randomized controlled trials investigat- ing the reduction of salivary load of SARS-CoV-2 using PVP-I were included. Ultimately, four arti- cles were included that met the established criteria. According to the current evidence, PVP-I is effective against SARS-CoV-2 in saliva and could be implemented as a rinse before interventions to decrease the risk of cross-infection in healthcare settings.

DESCARGAR ARTÍCULO

Allergy to penicillin and rheumatoid arthritis: A link that could play a role in the risk of implant failure.

British Journal of Oral and Maxillofacial Surgery 2022 [Ahead of Print]. DOI: 10.1016/bjoms.2022.01.013

Autores: Alvaro García-Sánchez, Angel-Orión Salgado-Peralvo and Juan-Francisco Peña-Cardelles.

Abstract: No abstract available.

DESCARGAR ARTÍCULO

Gender differences among professional dedicated to Oral Implantology in Spain: An observational study.

Journal of Clinical and Experimental Dentistry 2022; 14 (2); e153-7. DOI: 10.4317/jced.59263

Autores: Angel-Orión Salgado-Peralvo, Juan-Francisco Peña-Cardelles, Naresh Kewalramani, Álvaro Jiménez-Guerra, Eugenio Velasco-Ortega and Loreto Monsalve-Guil.

Abstract: 

Background: Despite the development of society and the educational progress achieved at the university education level, women continue to face obstacles that hinder their professional development. This study aims to determine whether there are gender differences in a representative sample of professionals dedicated to Oral Implantology in Spain.

Material and Methods: This is a cross-sectional observational study based on the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines. An electronic survey consisting of two blocks of questions was sent to members of the Spanish Society of Implants. The data were analyzed using descriptive analysis.

Results: A total of 303 participants (20.8%) responded to the questionnaire, of which 219 were men (72.3%) and 84 women (27.7%). Up to the age of 40 years, women predominate, whereas men predominate from the age of 51 years onwards, which is influenced by a greater number of years of experience in implant placement and a higher number of implants placed per year. Despite this, women have a higher level of training in Oral Implantology, as a greater proportion are trained through master’s degrees.

Conclusions: The greater representation of men in the study is associated with the ageing of the sample. The results obtained from the present study anticipate the trend of a greater presence of the female gender in Oral Implantology in Spain in the coming years.

DESCARGAR ARTÍCULO

Is Antibiotic Prophylaxis necessary before dental implant procedures in patients with Orthopaedic Prostheses? A Systematic Review

Antibiotics 2022; 11 (93). DOI: 10.3390/antibiotics11010093

Autores: Angel-Orión Salgado-Peralvo, Juan-Francisco Peña-Cardelles, Naresh Kewalramani, Álvaro García-Sánchez, María-Victoria Mateos-Moreno, Eugenio Velasco-Ortega, et al.

Abstract: As the population ages, more and more patients with orthopaedic prostheses (OPs) require dental implant treatment. Surveys of dentists and orthopaedic surgeons show that prophylactic antibiotics (PAs) are routinely prescribed with a very high frequency in patients with OPs who are about to undergo dental procedures. The present study aims to determine the need to prescribe prophylactic antibiotic therapy in patients with OPs treated with dental implants to promote their responsible use and reduce the risk of antimicrobial resistance. An electronic search of the MEDLINE database (via PubMed), Web of Science, LILACS, Google Scholar, and OpenGrey was carried out. The criteria used were those described by the PRISMA Statement. No study investigated the need to prescribe PAs in patients with OPs, so four studies were included on the risk of infections of OPs after dental treatments with varying degrees of invasiveness. There is no evidence to suggest a relationship between dental implant surgeries and an increased risk of OP infection; therefore, PAs in these patients are not justified. However, the recommended doses of PAs in dental implant procedures in healthy patients are the same as those recommended to avoid infections of OPs

DESCARGAR ARTÍCULO

Preventive Antibiotic Therapy in the Placement of Immediate Implants: A Systematic Review

Antibiotics 2022; 11 (1). DOI: 10.3390/antibiotics11010005

Autores: Angel-Orión Salgado-Peralvo, Juan-Francisco Peña-Cardelles, Naresh Kewalramani, María-Victoria Mateos-Moreno, Álvaro Jiménez-Guerra, Eugenio Velasco-Ortega, et al.

Abstract: Immediate implants present a high risk of early failure. To avoid this, preventive antibiotics (PAs) are prescribed; however, their inappropriate administration leads to antimicrobial resistance. The present study aims to clarify whether the prescription of PAs reduces the rate of early failure of immediate implants and to establish guidelines to avoid the overprescription of these drugs. An electronic search of the MEDLINE database (via PubMed), Web of Science, Scopus, LILACS and OpenGrey was carried out. The criteria described in the PRISMA® statement were used. The search was temporarily restricted from 2010 to 2021. The risk of bias was analysed using the SIGN Methodological Assessment Checklist for Systematic Reviews and Meta-Analyses and the JBI Prevalence Critical Appraisal Tool. After searching, eight studies were included that met the established criteria. With the limitations of this study, it can be stated that antibiotic prescription in immediate implants reduces the early failure rate. Preoperative administration of 2–3 g amoxicillin one hour before surgery followed by 500 mg/8 h for five to seven days is recommended. It is considered prudent to avoid the use of clindamycin in favour of azithromycin, clarithromycin or metronidazole in penicillin allergy patients until further studies are conducted.

DESCARGAR ARTÍCULO

 “Antibiotic prophylaxis” and “preventive antibiotic therapy”: Two sides of the same coin.

Journal of Stomatology Oral and Maxillofacial Surgery 2021; 20: S2468-7855(21)00278-0. DOI: 10.1016/j.jormas.2021.12.010

Autores: Angel-Orión Salgado-Peralvo, Naresh Kewalramani, Alvaro Garcia-Sanchez and Juan-Francisco Peña-Cardelles.

Abstract: Traditionally, preventive antibiotic prescription has been referred to as "antibiotic prophylaxis" (PA), but is this term correct in all cases? If oral and/or maxillofacial surgery is performed on a healthy patient, the surgeon will want to prevent infection of the surgical site, but if the same surgery is performed on a patient with certain medical conditions, i.e., with prosthetic cardiac valves, the main objective of prescribing antibiotics will be to prevent infective endocarditis.
In this letter to the Editor, we consider it appropriate to recommend the use of different specific terminology depending on the purpose for which preventive antibiotics are prescribed. If we want to prevent a surgical site infection, the correct term will be "preventive antibiotic therapy" (PAT).

DESCARGAR ARTÍCULO

Is Penicillin Allergy a Risk Factor for Early Dental Implant Failure? A Systematic Review

Antibiotics 2021; 10 (10): 1227. DOI: 10.3390/antibiotics10101227

Autores: Angel-Orión Salgado-Peralvo, Juan-Francisco Peña-Cardelles, Naresh Kewalramani, Iván Ortiz-García, Álvaro Jiménez-Guerra, Andrea Uribarri, Eugenio Velasco-Ortega, et al.

Abstract: The prescription of preventive antibiotics in dental implant treatments reduces the incidence of early failures. This study has focused mainly on the influence of amoxicillin, which is contraindicated in penicillin-allergic patients. The present systematic review aimed to determine whether penicillin-allergic patients have a higher risk of implant failure compared to non-allergic patients. An electronic search was performed on Medline and Web of Science using the following MeSH terms: (penicillin allergy OR clindamycin OR erythromycin OR azithromycin OR metronidazole) AND (dental implant OR dental implant failure OR dental implant complications). The criteria employed were those described in the PRISMA® Declaration. Only five articles were included that analyzed the failure rates of implants placed in penicillin-allergic patients who were prescribed clindamycin compared to non-allergic patients who were prescribed amoxicillin. With the limitations of this study, it is not possible to state that penicillin allergy per se constitutes a risk factor for early dental implant failure as most of the studies included self-reported allergic patients. Clindamycin has been associated with a significantly elevated risk of failure and an up to six times increased risk of infection. Immediate implants also have a 5.7 to 10 times higher risk of failure

DESCARGAR ARTÍCULO

Use of alternative drugs to penicillins as a possible risk factor in dental implant treatment

Journal of Stomatology Oral and Maxillofacial Surgery 2021; 3: S2468-7855(21)00145-2. DOI: 10.1016/j.jormas.2021.06.019

Autores: Angel-Orión Salgado-Peralvo, Juan-Francisco Peña-Cardelles, Naresh Kewalramani and Eugenio Velasco-Ortega.

Abstract: No abstract available.

DESCARGAR ARTÍCULO

Removal of a migrated dental implant from a maxillary sinus through an intraoral approach: A case report

Journal of Clinical and Experimental Research 2021; 13 (7): e733-6. DOI: 10.4317/jced.58350

Autores: Enrique Núñez-Márquez, Angel-Orión Salgado-Peralvo, Juan-Francisco Peña-Cardelles, Naresh Kewalramani,  Álvaro Jiménez-Guerra and Eugenio Velasco-Ortega.

Abstract: 

Background: The replacement of maxillary posterior teeth often challenges the clinician due to bone resorption after dental exodontia and low bone quality. Currently, attempts are being made to shorten treatment times by placing implants simultaneously to sinus lift procedures in borderline cases, which can lead to complications such as displacement of implants into the maxillary sinus.

Clinical case: A 54-year-old patient who was planned for complete rehabilitation of the maxilla through a fixed implant-supported prosthesis on 6 implants. At the level of the 3rd sextant, a sinus lift was performed with a lateral window approach (Caldwell-Luc type) and the simultaneous placement of two implants, one of which migrated into the sinus. The implant was displaced after 4 months when the second stage (uncovering) implant surgery was performed for the connection of the healing abutments. The implant was removed a week after the migration, since it had moved to the tuberosity area in the sinus and the lateral window had been performed in a more mesial position, so the patient was recommended to sleep on the right side to achieve the displacement of the implant to a more favourable area, removing it after a week through the same approach.

Discussion: Surgical strategies for the removal of a migrated implant are essentially divided into two main approaches: endoscopic transoral and endoscopic transnasal (and combined).

Conclusions: In case of intra-operative migration of the implant into the sinus, it is recommended to remove it as soon as possible to avoid a possible sinus pathology of iatrogenic origin. Key words:Dental implant complications, dental implant, dental implant displacement, maxillary sinus, case report.

DESCARGAR ARTÍCULO

Metal-free, implant-supported full-arch rehabilitation: Biopolymer reinforced for an implant-supported fixed prosthesis

Dentistry Today 2021.

Autores: Angel-Orión Salgado-Peralvo, Ángel Salgado-García, Juan-Francisco Peña-Cardelles, Naresh Kewalramani and Miguel Gómez-Polo.

Abstract: No abstract available.

DESCARGAR ARTÍCULO

Oral mucositis. Is it present in the immunotherapy of the immune checkpoint pd1/pd-l1 against oral cancer? A systematic review

Medicina Oral, Patología Oral y Cirugía Bucal 2021; 26 (4): e494-e501. DOI: 10.4317/medoral.24353

Autores: Juan-Francisco Peña-Cardelles, Angel-Orión Salgado-Peralvo,  Pablo Garrido-Martínez, José-Luis Cebrián-Carretero, José-Juan Pozo- Kreilinger, Jose-Ernesto Moro-Rodríguez.

Abstract: 

Background: Oral mucositis (OM) is a painful lesion that takes place in the mucosa of the oral cavity, usually its etiology is associated with drug therapies in cancer patients. It is presented as well-defined ulcers whose painful symptomatology sometimes implies the suspension of oncological treatment or parenteral feeding, being therefore an important adverse effect, marking the evolution of these types of therapies against cancer. The present work aim is to know the prevalence of oral mucositis in oral cancer immunotherapy compared to its prevalence in standard therapy.

Material and methods: A protocol was developed for a systematic review following PRISMA® guidelines and a focused question (PICO) was constructed. A comprehensive literature search was conducted on electronic databases including PubMed, the SCOPUS database, the Cochrane library and the Web of Science (WOS).

Results: Six clinical trials were included that met the different inclusion criteria. In these articles, a discrepancy between the prevalence of OM in patients treated with chemotherapy and patients treated with immunotherapy related to the immune checkpoint PD-1/PD-L1 (Nivolumab and Pembrolizumab) was observed.

Conclusions: The prevalence of oral mucositis is lower in new immunotherapy with monoclonal antibodies against oral cancer than drugs used so far (chemotherapy drugs [methotrexate, cisplatin] as well as cetuximab). However, more studies should be carried out to confirm these data.

DESCARGAR ARTÍCULO

Preventive Antibiotic Prescribing Habits among Professionals Dedicated to Oral Implantology: An Observational Study

Antibiotics 2021; 10 (3): 301. DOI: 10.3390/antibiotics10030301

Autores: Angel-Orión Salgado-Peralvo, Naresh Kewalramani, Juan-Francisco Peña-Cardelles,  María-Victoria Mateos-Moreno, Loreto Monsalve-Guil,  Álvaro Jiménez-Guerra, et al.

Abstract: The prescription of preventive antibiotics (PA) in oral implantology is a controversial issue. The study aimed to determine the prescribing habits of PA in professionals dedicated to oral implantology in various treatments in healthy and at-risk patients. This is a cross-sectional observational study based on the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines. An electronic survey consisting of 4 blocks of questions was sent to members of the Spanish Society of Implants. The data were analyzed using descriptive analysis. A total of 303 participants (20.8%) responded to the questionnaire. One percent never prescribed PA, 55.4% prescribed them always, and 43.6% prescribed them sometimes. Ninety-six percent adminis- tered them preoperatively, while 92.4% administered them postoperatively. The most commonly used antibiotic is amoxicillin followed by amoxicillin with clavulanic acid (875/125 mg). Clindamycin is the most commonly administered antibiotic in patients with allergies. Professionals dedicated to oral implantology frequently prescribe PA in both healthy and at-risk patients, especially perioperatively. Immediate implant placement, sinus lifts, bone regeneration, and multiple implant placement are the treatments in which PA are most commonly prescribed, as well as in patients with heart valve prostheses or a history of bacterial endocarditis and immunodeficiency.

DESCARGAR ARTÍCULO

Preventive antibiotic therapy in bone augmentation procedures in oral implantology: A systematic review

Journal of Stomatology Oral and Maxillofacial Surgery 2021; 22: S2468-7855(21)00035-5. DOI: 10.1016/j.jormas.2021.01.011

Autores: Angel-Orión Salgado-Peralvo, María-Victoria Mateos-Moreno, Eugenio Velasco-Ortega, Juan-Francisco Peña-Cardelles and Naresh Kewalramani.

Abstract: 

Introduction: Since the beginning of Oral Implantology, preventive antibiotic therapy has been routinely prescribed. However, at present, due to the growing appearance of antimicrobial resistance, its use has been questioned, generating a great debate and an emerging controversy. The present systematic review aims to analyze the scientific literature to determine whether the preventive prescription of antibiotics in augmentation procedures with the insertion of implants in one or two phases decreases the incidence of postoperative infections and/or the survival rate of the implants.

Material and methods: The MEDLINE database was searched (via PubMed) with the following keywords: (bone grafting OR alveolar ridge augmentation OR bone graft augmentation OR guided bone regeneration OR bone block) AND (dental implants OR dental implant OR oral implantology) AND (antibiotic prophylaxis OR antibiotics). The criteria used were those described by the PRISMA® Statement. The search was limited to randomised clinical trials, systematic reviews and meta-analyses published in the last 15 years (2005-2020).

Results: After reading the titles and abstracts of the resulting articles, only one systematic review meeting the described criteria and 4 randomised clinical trials were included.

Conclusions: Prescription of 2 or 3 g of amoxicillin one hour before surgery is recommended to reduce the early failure rate of one-stage implants and to decrease the bacterial load of grafted bone particles in bone augmentation procedures with one or two-stage implants.

DESCARGAR ARTÍCULO

Cancerous lesions in the vicinity of dental implants: a systematic review

Journal of  Oral Medicina and Oral Surgery 2020; 26 (4): 45. DOI: 10.1051/mbcb/2020040

Autores: Angel-Orión Salgado-Peralvo, Victor Serrano-Sánchez, Iris Vaello-Checa, Alexandra Helm, María-Victoria Mateos-Moreno and Alberto Salgado-Velázquez.

Abstract: 

Introduction: The massive diffusion of dental implant treatments in the last decades leads to the appearance of complications, most of them inflammatory, although important complications have been described as malignant lesions in the vicinity of dental implants. The objective of this article is to describe the cases described in the literature of oral squamous cell carcinoma (OSCC) or clinical variants and metastases, in the vicinity of dental implants and to analyze the possible etiological agents involved. 

Material and methods: The criteria used were those described in the PRISMA® Declaration for performing systematic reviews. An electronic search was performed on MEDLINE (via PubMed) using the terms MeSH: “dental implants” AND “squamous cell carcinoma” OR “dental implant complications” AND “squamous cell carcinoma”. 

Results: Thirty-eight articles describing a total of 76 cases of OSCC or clinical variants, as well as metastasis in the vicinity of dental implants, were included.

Conclusions: It is not possible to establish a cause-effect relationship between dental implants and the development of OSCC. Its clinical appearance can be confused with periimplantitis, so that, in cases of sudden onset, which do not respond to conventional treatment and/or have associated alterations in sensitivity, a biopsy should be performed.

DESCARGAR ARTÍCULO

Profilaxis antibiótica en implantología oral. Revisión crítica de la literatura

Revista Española de Cirugía Oral y Maxilofacial  2019; 41 (2): 80-90. DOI: 10.20986/recom.2019.1011/2018

Autores: Angel-Orión Salgado-Peralvo, Javier Sanz-Esporrin, María-Victoria Mateos-Moreno, Ahmad Haidar-Wehbe, Andrés Blanco-Carrión y Eugenio Velasco-Ortega.

Abstract: La masiva difusión de los tratamientos implantológicos conlleva, según los patrones de prescripción actuales, la administración de antibióticos profilácticos, los cuales no están indicados en la mayoría de los casos; sin embargo, su uso suele basarse en la experiencia del operador, en muchos casos influenciado por presiones legales. El desarrollo creciente a nivel mundial de resistencias bacterianas a la casi totalidad de familias de antibióticos conocidos provoca que cada vez sea mayor el número de infecciones cuyo tratamiento se vuelve más complicado debido a la pérdida de eficacia de estos fármacos, lo que constituye un problema fundamental de salud pública.

La evidencia disponible respecto a la prescripción profiláctica antibiótica en tratamientos de implantes muestra que la administración de 2 gramos de amoxicilina, 1 hora antes de la intervención, disminuye significativamente el riesgo de fracaso temprano, no así el riesgo de infección. Pese a ello, no está justificado su uso indiscriminado, sino que se debería prescribir en pacientes en riesgo de sufrir una endocarditis bacteriana, en pacientes inmu- nodeprimidos, en la inserción de implantes en alvéolos infectados, en cirugías extensas y prolongadas, y en cirugías regenerativas por un mayor riesgo de dehiscencia mucosa, debido a un mayor riesgo de infección asociada a estos casos. Su prescripción en pacientes sanos, sin condicionantes anatómicos y en lechos quirúrgicos con una correcta calidad ósea no estaría justificado.
 

DESCARGAR ARTÍCULO

Novedades técnicas en implantes subperiósticos: Ranc-implants. A propósito de un caso

Revista Española de Cirugía Oral y Maxilofacial  2019; 41 (1):33-4. DOI: 10.20986/recom.2019.1021/2019

Autores: Emilio-Adolfo Rancaño-Álvarez y Ángel-Orión Salgado-Peralvo.

Abstract: No abstract available.
 

DESCARGAR ARTÍCULO

Bariatric surgery as a risk factor in the development of dental caries: A systematic review

Public Health  2018; 155: 26-34. DOI: 10.1016/j.puhe.2017.11.013

Autores: Ángel-Orión Salgado-Peralvo, María-Victoria Mateos-Moreno, Lorenzo Arriba-Fuente, Alvaro García-Sánchez, Angel Salgado-García, Victoria Peralvo-García and María Millán-Yanes.

Abstract: 

Objectives: Obesity is one of the most prevalent chronic pathologies in the world and has become a public health problem. At the present time, bariatric surgery (BS) is considered the best option and the only effective method of treatment, but it can occasionally result in a series of alterations at the oral level. This study aims to review the current literature to establish the possible association of patients who have undergone BS and a greater risk of dental caries.

Study design: This study is a systematic review of the literature.

Methods: A search was made in the database of Medline (via PubMed), over the last 10 years, using the keywords 'bariatric surgery' OR 'gastrectomy' OR 'obesity surgery,' combined independently with the terms 'saliva' and 'dental caries' by means of the connector 'AND.' The criteria used were those described in the PRISMA® Declaration for performing systematic reviews. Inclusion criteria and study selection: (a) studies done with humans; (b) articles published in English and Spanish; (c) series of cases; and (d) clinical trials. The risk of bias was assessed independently by two authors. In both data extraction and risk of bias assessment, disagreements were resolved through discussion with a third author.

Results: Two independent reviewers read the titles and summaries of the 79 articles found. Finally, nine of them were included in the study. In the various articles, the parameters that had clinical relevance to the risk of dental caries were evaluated.

Conclusions: Within the limitations of this study, it is plausible to think that patients who have undergone BS have a greater risk of dental caries. The oral complications associated with BS could be prevented or minimized by including in the multidisciplinary treatment of these patients a team of odontologists who would be responsible for prevention and oral assessment.
 

DESCARGAR ARTÍCULO

Nuevas tendencias en regeneración tisular: fibrina rica en plaquetas y leucocitos

Revista Española de Cirugía Oral y Maxilofacial  2017; 39 (2):91-8. DOI: 10.1016/j.maxilo.2016.03.001

Autores: Ángel-Orión Salgado-Peralvo, Angel Salgado-García y Lorenzo Arriba-Fuente.

Abstract: La regeneración periodontal es la reproducción o reconstitución de una parte perdida o dañada del periodonto con el fin de restaurar su arquitectura y función. En los últimos años se ha puesto de manifiesto el papel clave que juegan las plaquetas en la regeneración tisular, acelerando la cicatrización tanto de tejidos blandos como duros, mediada por la liberación de citocinas y factores de crecimiento durante un tiempo prolongado. La fibrina rica en plaquetas y leucocitos utilizada por primera vez por Choukroun en el 2001 es un concentrado de plaquetas de segunda generación que se obtiene a partir de la propia sangre del paciente, sin el empleo de aditivos, con el fin de conseguir una malla de fibrina que sirva de andamiaje para las sustancias implicadas en la regeneración. El objetivo de este trabajo es el de realizar una revisión y puesta al día en el uso de esta técnica.

DESCARGAR ARTÍCULO

Is there an association between dental implants and squamous cell carcinoma?

British Dental Journal  2016; 221 (10): 645-9. DOI: 10.1038/sj.bdj.2016.863

Autores: Ángel-Orión Salgado-Peralvo,  Lorenzo Arriba-Fuente, María-Victoria Mateos-Moreno and Angel Salgado-García.

Abstract: 

Introduction: The complications associated with dental implants are numerous, most of them of an inflammatory nature; nevertheless, some isolated cases of oral squamous cell carcinoma (OSCC) have been found in the vicinity of the implants. The objective of the present article is to know whether there is an association between dental implants and the development of OSCC.

Method and materials: A search was carried out in Medline, Tripdatabase and Cochrane with the keywords 'dental implants' AND 'squamous cell carcinoma', and 'dental implant complications' AND 'squamous cell carcinoma.' The criteria for inclusion were articles published in English that dealt with the possible carcinogenic effects of implants and the possible malign transformation of oral lesions after the insertion of the implants. For the analysis, cases were used in which an OSCC had appeared in the peri-implantary mucosa.Results After an initial search, 269 articles were selected, of which 197 were excluded as not being directly related to the subject. Finally, 45 articles were selected, with 23 of them being used in the analysis. In these, 46 cases of OSCC in the vicinity of implants were discussed.

Discussion: Chronic inflammation in itself can lead to a malign transformation of the oral tissue, while in other cases it is caused and modulated by carcinogens, genetic factors or inherent factors in the patient, or by the dental implants.

Conclusions: It is not possible to establish a cause-effect relation between the implants and the development of OSCC. Its presence can be confused with peri-implantitis, so that in the cases where it appears suddenly, does not respond to conventional treatment and/or there is anaesthesia or paresthesia, it is advisable to do a biopsy. It is important to make an adequate selection of the patient and reduce or eliminate the risk factors. The findings of the present review are based on case study level of evidence, so meta-analysis is needed to further draw from these results.
 

DESCARGAR ARTÍCULO